A simple and reliable sign for early diagnosis of ischemic cardiomyopathy – an incurable fatal heart disease – was found by scientists from the Siberian State Medical University (SSMU). According to them, the detection of pathology at an early stage will increase the effectiveness of therapy and reduce mortality. The research results are published in the IJC Heart & # 38; Vasculature.
In ischemic cardiomyopathy (ICM), the left ventricle of the heart expands and its walls become thinner, which greatly reduces the ability to pump blood. According to the researchers of the Siberian State Medical University, this pathology is one of the main causes of death from chronic heart failure in patients over 50 years of age: ICMP develops in 5-8 percent of patients with coronary heart disease and in 30 percent of those who have had myocardial infarction.
When the body is restored in the postinfarction period, macrophages M1 first enter the affected areas of the myocardium – special scavenger cells that eliminate dead tissue. Then they are replaced by macrophages of the M2 type, which stimulate the growth of connective tissue to fill in the defects. In patients with ICMP, the second stage of macrophage work never ends. This leads to the proliferation of “cicatricial” connective tissue, incapable of contraction and conduction of electrical impulses.